• Corpus ID: 75811795

Comparison between effect of fenofibrate sustained release pellet capsule and simvastatin in treating combined hyperlipidemia

@article{Rumin2002ComparisonBE,
  title={Comparison between effect of fenofibrate sustained release pellet capsule and simvastatin in treating combined hyperlipidemia},
  author={He Ru-min},
  journal={Chinese Journal of New Drugs and Clinical Remedies},
  year={2002}
}

• He Ru-min
• Published 2002
• Medicine, Biology, Chemistry
• Chinese Journal of New Drugs and Clinical Remedies

AIM: To compare effect and safety of fenofibrate sustained release pellet capsule (Lip) vs simvastatin (Sim) in treating IIb hyperlipidemia in chinese crowds. METHODS: One hundred and forty-three patients with combined hyperlipidemia were randomly divided into two groups. Lip group (n=72) was treated with fenofibrate 250 mg·d -1, po, qd for 6 wk while Sim group (n=71) was treated with simvastatin 10 mg·d -1, po, qd for 6 wk. RESULTS: TC, TG, LDL-C, and (TC-HDL-C)/HDL-C in both groups significantly reduced after 6 wk treatment. The HDL-C increased in different degree. The reduction of serum TG was more significant in Lip group than that in Sim group[ (1.2± 0.8) mmol·L -1 vs (0.8± 0.7) mmol·L -1,P 0.01], while TC and LDL-C levels were significient higher in Sim group than those in Lip group [(1.6± 1.0) mmol·L -1 vs (1.0± 1.0) mmol·L -1, P 0.01] . There was no significant difference in total efficacy between two groups (92% vs 94%) (P 0.05). CONCLUSION: Fenofibrate is an effective and safe drug in treating IIb hyperlipidemia as well as simvastatin.