Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.

@article{Toegel2008ComparisonBC,
  title={Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1beta-stimulated C-28/I2 chondrocytes.},
  author={Stefan Toegel and S. Q. Wu and Claudia Piana and Frank Michael Dr Unger and Michael. Wirth and Mary B Goldring and Franz Gabor and Helmut Viernstein},
  journal={Osteoarthritis and cartilage},
  year={2008},
  volume={16 10},
  pages={
          1205-12
        }
}
OBJECTIVE To compare the effects of glucosamine (GlcN), curcumin, and diacerein in immortalized human C-28/I2 chondrocytes at the cellular and the gene expression level. This study aimed to provide insights into the proposed beneficial effects of these agents and to assess the applicability of the C-28/I2 cell line as a model for the evaluation of chondroprotective action. METHODS Interleukin-1beta (IL-1beta)-stimulated C-28/I2 cells were cultured in the presence of GlcN, curcumin, and… Expand
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We are writing in response to the recent paper by Toegel et al. (2008) Osteoarthritis and Cartilage comparing the chondroprotective effects of glucosamine, curcumin and diacerein in interleukinExpand
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