Comparison between Sendai virus and adenovirus vectors to transduce HIV‐1 genes into human dendritic cells
@article{Hosoya2008ComparisonBS, title={Comparison between Sendai virus and adenovirus vectors to transduce HIV‐1 genes into human dendritic cells}, author={Noriaki Hosoya and Toshiyuki Miura and Ai Kawana-Tachikawa and Tomohiko Koibuchi and Tatsuo Shioda and Takashi Odawara and Tetsuya Nakamura and Y. Kitamura and Munehide Kano and Atsushi Kato and Mamoru Tsukuba-shi Hasegawa and Yoshiyuki Nagai and Aikichi Iwamoto}, journal={Journal of Medical Virology}, year={2008}, volume={80} }
Immuno‐genetherapy using dendritic cells (DCs) can be applied to human immunodeficiency virus type 1 (HIV‐1) infection. Sendai virus (SeV) has unique features such as cytoplasmic replication and high protein expression as a vector for genetic manipulation. In this study, we compared the efficiency of inducing green fluorescent protein (GFP) and HIV‐1 gene expression in human monocyte‐derived DCs between SeV and adenovirus (AdV). Human monocyte‐derived DCs infected with SeV showed the maximum…
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References
SHOWING 1-10 OF 58 REFERENCES
Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy.
- BiologyBlood
- 2005
Viral transduction of virally infected DCs results in up-regulation of the indoleamine 2,3-dioxygenase (IDO) enzyme, which down-regulates T-cell responsiveness, indicating that IDO is responsible for the modulation of mDC function.
Efficiency of cross presentation of vaccinia virus‐derived antigens by human dendritic cells
- BiologyEuropean journal of immunology
- 2001
The ability of DC to cross‐present vaccinia‐derived antigens from infected apoptotic cells or necrotic cell lysates, bypasses the deleterious effects of direct infection of DC and provides one explanation for this pathogen's immunogenicity.
Engineered expression of the Coxsackie B and adenovirus receptor (CAR) in human dendritic cells enhances recombinant adenovirus-mediated gene transfer.
- BiologyJournal of immunological methods
- 2002
Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro
- BiologyGene Therapy
- 1999
The potential of adenovirus vectors in the transduction of human DC for the induction of antigen-specific T-lymphocyte responses against a defined vector-encoded antigen is demonstrated and provided an important link between existing animal data and human clinical application.
Yeast-Derived Human Immunodeficiency Virus Type 1 p55gag Virus-Like Particles Activate Dendritic Cells (DCs) and Induce Perforin Expression in Gag-Specific CD8+ T Cells by Cross-Presentation of DCs
- BiologyJournal of Virology
- 2003
The results suggest that DCs loaded with yeast VLPs can activate Gag-specific memory CD8+ T cells to become effector cells in chronically HIV-infected individuals, but there still remain unresponsive GAG-specific T-cell populations in these patients.
Sendai virus‐based expression of HIV‐1 gp120: reinforcement by the V(−) version
- BiologyGenes to cells : devoted to molecular & cellular mechanisms
- 1997
A system for recovering Sendai virus (SeV), a nonsegmented negative strand RNA virus, entirely from cDNA at an extremely high rate is established, and a V(−) SeV whose gene expression was greatly enhanced by the deletion of the nonessential V gene is created.
Mature Dendritic Cells Infected with Canarypox Virus Elicit Strong Anti-Human Immunodeficiency Virus CD8+and CD4+ T-Cell Responses from Chronically Infected Individuals
- BiologyJournal of Virology
- 2001
Canarypox virus-infected DCs were directly able to stimulate HIV-specific, IFN-γ-secreting CD4 helper responses from bulk as well as purified CD4+ T cells, suggesting that targeting canarypoxirus vectors to mature DCs could potentially elicit both anti-HIV CD8+ and CD4- helper responses in vivo.
Human Cytomegalovirus pp65- and Immediate Early 1 Antigen-Specific HLA Class I-Restricted Cytotoxic T Cell Responses Induced by Cross-Presentation of Viral Antigens1
- Biology, MedicineThe Journal of Immunology
- 2001
It is shown that uninfected DCs induce CD8+ T cell cytotoxicity and IFN-γ production against H CMV pp65 and immediate early 1 Ags following in vitro coculture with HCMV-AD169-infected Fbs, regardless of the HLA type of these Fbs.
Primary replication of a recombinant Sendai virus vector in macaques.
- BiologyThe Journal of general virology
- 2002
Gag expression was undetectable in the lung as well as in remote lymphoid tissues, such as the thymus, spleen and inguinal LN, indicating that the spread of the virus was more restricted in macaques than in mice.
Adenoviruses Activate Human Dendritic Cells without Polarization toward a T-Helper Type 1-Inducing Subset
- BiologyJournal of Virology
- 1999
It is shown that infection by rAd enhances the immunostimulatory capacity of immature human monocyte-derived DC through the upregulation of the costimulatory molecules CD80, CD86, and CD40 and the major histocompatibility complex class I and II molecules.