Comparison between Sendai virus and adenovirus vectors to transduce HIV‐1 genes into human dendritic cells

  title={Comparison between Sendai virus and adenovirus vectors to transduce HIV‐1 genes into human dendritic cells},
  author={Noriaki Hosoya and Toshiyuki Miura and Ai Kawana-Tachikawa and Tomohiko Koibuchi and Tatsuo Shioda and Takashi Odawara and Tetsuya Nakamura and Y. Kitamura and Munehide Kano and Atsushi Kato and Mamoru Tsukuba-shi Hasegawa and Yoshiyuki Nagai and Aikichi Iwamoto},
  journal={Journal of Medical Virology},
Immuno‐genetherapy using dendritic cells (DCs) can be applied to human immunodeficiency virus type 1 (HIV‐1) infection. Sendai virus (SeV) has unique features such as cytoplasmic replication and high protein expression as a vector for genetic manipulation. In this study, we compared the efficiency of inducing green fluorescent protein (GFP) and HIV‐1 gene expression in human monocyte‐derived DCs between SeV and adenovirus (AdV). Human monocyte‐derived DCs infected with SeV showed the maximum… 
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