Comparison and functional implications of the 3D architectures of viral tRNA-like structures.

@article{Hammond2009ComparisonAF,
  title={Comparison and functional implications of the 3D architectures of viral tRNA-like structures.},
  author={John A. Hammond and Robert P. Rambo and Megan E. Filbin and Jeffrey S Kieft},
  journal={RNA},
  year={2009},
  volume={15 2},
  pages={294-307}
}
RNA viruses co-opt the host cell's biological machinery, and their infection strategies often depend on specific structures in the viral genomic RNA. Examples are tRNA-like structures (TLSs), found at the 3' end of certain plant viral RNAs, which can use the cell's aminoacyl tRNA-synthetases (AARSs) to drive addition of an amino acid to the 3' end of the viral RNA. TLSs are multifunctional RNAs involved in processes such as viral replication, translation, and viral RNA stability; these… CONTINUE READING