Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

@inproceedings{Saeed2014ComparisonBS,
  title={Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant},
  author={Muhammad Qamar Saeed and Noelle Dufour and Cynthia Bartholmae and Urzula Sieranska and Malaika Knopf and Elo{\"i}se Thierry and Sylvain Thierry and Olivier Delelis and Nicolas Grandchamp and H{\'e}lo{\"i}se Pilet and Philippe Ravassard and Julie Massonneau and Francoise Pflumio and Christof von Kalle and François Lachapelle and Alexis-Pierre Bemelmans and Manfred Schmidt and Ch{\'e} Serguera},
  booktitle={Molecular therapy. Nucleic acids},
  year={2014}
}
HIV-1 derived vectors are among the most efficient for gene transduction in mammalian tissues. As the parent virus, they carry out vector genome insertion into the host cell chromatin. Consequently, their preferential integration in transcribed genes raises several conceptual and safety issues. To address part of these questions, HIV-derived vectors have been engineered to be nonintegrating. This was mainly achieved by mutating HIV-1 integrase at functional hotspots of the enzyme enabling the… CONTINUE READING
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