Comparing three screening strategies for combining first- and second-trimester Down syndrome markers.

@article{Palomaki2006ComparingTS,
  title={Comparing three screening strategies for combining first- and second-trimester Down syndrome markers.},
  author={Glenn E Palomaki and Klaus Steinort and George J. Knight and James E. Haddow},
  journal={Obstetrics and gynecology},
  year={2006},
  volume={107 2 Pt 1},
  pages={367-75}
}
OBJECTIVE To describe the choices and tradeoffs inherent in 3 published strategies that combine first- and second-trimester markers for Down syndrome screening. METHODS Published marker distributions for Down syndrome and unaffected pregnancies in the first and second trimesters were combined with a maternal age distribution and age-associated Down syndrome risk in a statistical model to compare sequential, contingent, and integrated screening. RESULTS Sequential and contingent screening… CONTINUE READING