Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers

@article{Hill2000ComparingTS,
  title={Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers},
  author={Joanna L. Hill and James P. Zacny},
  journal={Psychopharmacology},
  year={2000},
  volume={152},
  pages={31-39}
}
Rationale: The psychopharmacological profile of hydromorphone, an opioid that has been used extensively for many years for post-operative pain management, has not been adequately characterized in non-drug abusers. Objectives: To characterize the subjective, psychomotor, and physiological effects of a range of single doses of hydromorphone in non-drug-abusing volunteers and to compare the effects of hydromorphone with that of morphine, a benchmark mu opioid agonist. Methods: Subjects in a six… CONTINUE READING

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