• Biology, Medicine
  • Published in Journal of immunology 1999

Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.

@article{Kreuwel1999ComparingTR,
  title={Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.},
  author={Huub T. C. Kreuwel and David J. Morgan and Troy Krahl and Alice Ko and Nora E. Sarvetnick and Linda A Sherman},
  journal={Journal of immunology},
  year={1999},
  volume={163 8},
  pages={
          4335-41
        }
}
CD8+ cytotoxic T cells play a critical role in initiating insulin-dependent diabetes mellitus. The relative contribution of each of the major cytotoxic pathways, perforin/granzyme and Fas/Fas ligand (FasL), in the induction of autoimmune diabetes remains controversial. To evaluate the role of each lytic pathway in beta cell lysis and induction of diabetes, we have used a transgenic mouse model in which beta cells expressing the influenza virus hemagglutinin (HA) are destroyed by HA-specific CD8… CONTINUE READING

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