Comparing the relative amount of testosterone required to restore sexual arousal, motivation, and performance in male rats

@article{Harding2011ComparingTR,
  title={Comparing the relative amount of testosterone required to restore sexual arousal, motivation, and performance in male rats},
  author={Shannon M. Harding and Jonathan P. Velotta},
  journal={Hormones and Behavior},
  year={2011},
  volume={59},
  pages={666-673}
}
It is well established that male rat reproductive behaviors including sexual arousal, motivation, and performance are dependent on circulating levels of testosterone (T). The present study was designed to (1) compare the relative amount of T required to restore these different aspects of behavior in castrated rats, and (2) create an animal model for clinical populations with sexual impairments. Twenty-nine male Long-Evans rats were tested before and after castration for sexual performance… 
Effects of chronic estradiol or testosterone treatment upon sexual behavior in sexually sluggish male rats
TLDR
The results suggest that the lack of ejaculation patter in SS male rats is not due to estrogenic or androgenic alteration.
The role of estrogen G-protein coupled receptor 30 (GPR30) and sexual experience in sexual incentive motivation in male rats
TLDR
Results indicate that interference with estrogen signaling at GPR30 reduces sexual motivation and that the lack of preference for a sexually receptive female rat over a male rat following G-15 treatment is abrogated by previous sexual experience.
Deficits in male sexual behavior in adulthood after social instability stress in adolescence in rats
TLDR
The results suggest that developmental history contributes to individual differences in reproductive behavior, and that stress exposures in adolescence may be a factor in sexual sluggishness.
Sexual Motivation in Male Rats is Modulated by Tropomyosin Receptor Kinase B (TrkB)
TLDR
Results suggest that TrkB plays a role in the sexual preferences and corresponding initial levels of sexual motivation in male rats.
Testosterone or Oestradiol Implants in the Medial Preoptic Area Induce Mating in Noncopulating Male Rats
TLDR
The hypothesis that, in the MPOA of NC male rats, there is a hormonal alteration associated with the lack of sexual behaviour is supported.
Learning and the Lifespan: What’s Sex Got to Do With It?
TLDR
It is suggested that T metabolites, but not the prohormone, may influence learning dependent on sexual proclivity, experience, and proximate opportunity to mate, as well as in sexually experienced rats.
Do rats have orgasms?
TLDR
The ability to infer OLRs in rats offers new possibilities to study the phenomenon in neurobiological and molecular detail, and to provide both comparative and translational perspectives that would be useful for both basic and clinical research.
Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression
TLDR
The results suggest that maternal exposure to glyphosate disturbed the masculinization process and promoted behavioral changes and histological and endocrine problems in reproductive parameters.
The effects of repeated forced ethanol consumption during adolescence on reproductive behaviors in male rats.
TLDR
The findings indicate that repeated, intermittent ethanol exposure may have moderate effects on reproductive behavior that vary as a function of age.
1.01 – Male Sexual Behavior
TLDR
Drugs affecting dopamine, norepinephrine, serotonin, glutamate, gamma-aminobutyric acid, opioids, nitric oxide, oxytocin, and orexin/hypocretin administered systemically or into specific brain areas influence mating.
...
1
2
3
...

References

SHOWING 1-10 OF 63 REFERENCES
Effects of testosterone in the VMN on copulation, partner preference, and vocalizations in male rats
TLDR
It is suggested that androgen activation at the VMN is sufficient to induce the motivational components of male sexual behavior, whereas activation of other brain sites is required for copulation and ultrasonic vocalization.
Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats.
TLDR
The data suggest that relatively high and prolonged levels of E2R occupation are required for estrogen activation of male sexual behavior, and that in intact male rats T, acting via androgen receptors, plays a primary role in mediating the expression of masculine sexual behavior.
Role of aromatization in anticipatory and consummatory aspects of sexual behavior in male rats
TLDR
The view that aromatization is important for maintaining both the appetitive and the consummatory aspects of sexual behavior in male rats is supported.
The Role of Aromatization in the Restoration of Male Rat Reproductive Behavior
TLDR
The results lend support to the hypothesis that both androgen receptor activation and aromatization are necessary for the restoration of male sexual behavior in rats and found that estradiol is neither necessary nor sufficient for the restored of partner preference.
Sexually stimulated testosterone release in male mice (Mus musculus): Roles of genotype and sexual arousal
TLDR
Four experiments using house mice examined the hypothesis that both the male's genotype and his degree of sexual arousal (as indexed by ultrasonic mating calls) are related to such variability as well as statistically significant correlations between mating calls in the first minute after stimulus exposure and testosterone elevations 30 min later.
Critical exposure time for androgen activation of male sexual behavior in rats
TLDR
It is demonstrated that, although relatively brief (less than or equal to 18 hr/day) exposures to testosterone can activate mounts and intromissions, significantly more responses are found in males receiving at least 21 hr of T exposure per day.
Both estrogen receptors and androgen receptors contribute to testosterone-induced changes in the morphology of the medial amygdala and sexual arousal in male rats
TLDR
Both androgen receptors and estrogen receptors appear to participate in sexual behaviors that may be mediated by the MePD in adult rats, and both receptors contribute to the steroid-regulated structural plasticity in this brain region.
Effects of estrogen on the sexual behavior of male rats.
TLDR
Large doses of EB suppressed the homotypical behavior of normal males, but had a slight stimulatory effect in long-term castrates, and produced “androgenic” effects on homotypesical behavior.
Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.
TLDR
Results indicate that both anticipatory and consummatory measures of sexual behavior were disrupted by DA receptor antagonists; however, the measure of anticipatory sexual behavior was more sensitive to disruption than consummatories measures of copulation.
Estrogen-activated sexual behavior in male rats.
TLDR
It is suggested that estrogen has central “androgen-like” effects, but no such effects in the periphery, as compared to testosterone propionate, which resulted in testicular atrophy and loss of body weight, but had no significant effects on the sexual behavior.
...
1
2
3
4
5
...