Comparing the human and chimpanzee genomes: searching for needles in a haystack.

@article{Varki2005ComparingTH,
  title={Comparing the human and chimpanzee genomes: searching for needles in a haystack.},
  author={Ajit Varki and Tasha K. Altheide},
  journal={Genome research},
  year={2005},
  volume={15 12},
  pages={1746-58}
}
The chimpanzee genome sequence is a long-awaited milestone, providing opportunities to explore primate evolution and genetic contributions to human physiology and disease. Humans and chimpanzees shared a common ancestor approximately 5-7 million years ago (Mya). The difference between the two genomes is actually not approximately 1%, but approximately 4%--comprising approximately 35 million single nucleotide differences and approximately 90 Mb of insertions and deletions. The challenge is to… CONTINUE READING