Comparing the human and chimpanzee genomes: searching for needles in a haystack.

@article{Varki2005ComparingTH,
  title={Comparing the human and chimpanzee genomes: searching for needles in a haystack.},
  author={A. Varki and T. K. Altheide},
  journal={Genome research},
  year={2005},
  volume={15 12},
  pages={
          1746-58
        }
}
The chimpanzee genome sequence is a long-awaited milestone, providing opportunities to explore primate evolution and genetic contributions to human physiology and disease. Humans and chimpanzees shared a common ancestor approximately 5-7 million years ago (Mya). The difference between the two genomes is actually not approximately 1%, but approximately 4%--comprising approximately 35 million single nucleotide differences and approximately 90 Mb of insertions and deletions. The challenge is to… Expand
Lessons from Chimpanzee-based Research on Human Disease: The Implications of Genetic Differences
  • Jarrod Bailey
  • Biology, Medicine
  • Alternatives to laboratory animals : ATLA
  • 2011
Reconstructing phylogenies and phenotypes: a molecular view of human evolution
THE CHIMPANZEE GENOME AND THE PROBLEM OF BIOLOGICAL SIMILARITY
Global discovery of primate-specific genes in the human genome
Unique and Universal Proteins in Human Genome
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 139 REFERENCES
A genome-wide survey of structural variation between human and chimpanzee.
Genetic differences between humans and great apes.
A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees
Duplication and positive selection among hominin-specific PRAME genes
A genome-wide comparison of recent chimpanzee and human segmental duplications
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
...
1
2
3
4
5
...