Comparing the evolutionary conservation between human essential genes, human orthologs of mouse essential genes and human housekeeping genes

@article{Lv2015ComparingTE,
  title={Comparing the evolutionary conservation between human essential genes, human orthologs of mouse essential genes and human housekeeping genes},
  author={Wenhua Lv and Jiajia Zheng and Meiwei Luan and Miao Shi and Hongjie Zhu and Mingming Zhang and Hongchao Lv and Zhenwei Shang and Lian Duan and Ruijie Zhang and Yongshuai Jiang},
  journal={Briefings in bioinformatics},
  year={2015},
  volume={16 6},
  pages={
          922-31
        }
}
Human housekeeping genes are often confused with essential human genes, and several studies regard both types of genes as having the same level of evolutionary conservation. However, this is not necessarily the case. To clarify this, we compared the differences between human housekeeping genes and essential human genes with respect to four aspects: the evolutionary rate (dN/dS), protein sequence identity, single-nucleotide polymorphism (SNP) density and level of linkage disequilibrium (LD). The… 
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