Comparing the efficacy of NSAIDs and paracetamol in children

@article{Anderson2004ComparingTE,
  title={Comparing the efficacy of NSAIDs and paracetamol in children},
  author={Brian J. Anderson},
  journal={Pediatric Anesthesia},
  year={2004},
  volume={14}
}
  • B. Anderson
  • Published 1 March 2004
  • Medicine
  • Pediatric Anesthesia
Paracetamol (acetaminophen) and the nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in children for antipyresis and analgesia. The anti-inflammatory properties of the NSAIDs have, in addition, been used in such diverse disorders as juvenile idiopathic arthritis, Kawasaki disease and cystic fibrosis (1–4). The NSAIDs indomethacin and ibuprofen are also used to treat delayed closure of patent ductus arteriosus (PDA) in premature infants (5). Paracetamol and NSAIDs are often given… 
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Paracetamol: a focus for the general pediatrician
TLDR
Although frequently prescribed, the concept of “effect compartment concentration” and the possible co-factors that could cause toxicity at recommended doses are not familiar to all pediatricians and general practitioners.
Do not add to the stress: is paracetamol prescription well tolerated by children?
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The mechanism responsible for this causative role of paracetamol in asthma lies in a par acetamol-induced reduction in glutathione levels, which results in an increased oxidantinduced inflammation and subsequent enhancement in T-helper type 2 immunological responses.
Rectal Diclofenac Versus Rectal Paracetamol: Comparison of Antipyretic Effectiveness in Children
TLDR
In the first one hour, Diclofenac suppository is able to control the fever more efficient than Paracetamol suppositories.
Adverse drug reactions to nonsteroidal anti-inflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital.
TLDR
NSAID exposures are a significant cause of morbidity in children and the overall severity of these ADRs highlights the need for vigilant surveillance of ADRs in paediatrics, including both established and newer agents.
Use of nonsteroidal anti‐inflammatory drugs in infants. A survey of members of the Association of Paediatric Anaesthetists of Great Britain and Ireland
TLDR
The dose and interval in children is currently extrapolated from adult studies, as the pharmacokinetic (PK) and pharmacodynamic (PD) data are lacking in infants.
Paracetamol as a basic component of a modern approach to adequate perioperative analgesia
TLDR
Intravenous paracetamol is a safe and effective first-line drug for the treatment of moderate pain in the perioperative period and the mechanism of action of the drug is still not fully understood.
EFFECTIVENESS OF ANALGESIA IN YOUNG CHILDREN POST TONSILLECTOMY- CASE STUDY AFRICA HOSPITAL
TLDR
There were significant association between dosage forms, age and pain score, and the incidence of nausea, vomiting and bleeding was less frequent in the population indicating safety of analgesics used, indicating that post operative pain in young patients undergoing tonsillectomy is safe.
Paracetamol (Acetaminophen) Penetrates Readily Into the Cerebrospinal Fluid of Children After Intravenous Administration
TLDR
Paracetamol permeates readily into the cerebrospinal fluid of children, which enables the rapid central analgesic and antipyretic action of intravenous par acetamol.
Randomized controlled trial of duration of analgesia following intravenous or rectal acetaminophen after adenotonsillectomy in children.
TLDR
Rectal acetaminophen 40 mg kg(-1) rectally provides longer analgesia for moderately painful procedures when compared with 15 mg kg (-1)acetaminophen i.v. during adenotonsillectomy.
Rectal acetaminophen does not reduce morphine consumption after major surgery in young infants.
TLDR
Acetaminophen, as an adjuvant to continuous morphine infusion, does not have an additional analgesic effect and should not be considered as standard of care in young infants, 0-2 months of age, after major thoracic (non-cardiac) or abdominal surgery.
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