Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus

@article{Chen2008ComparingTA,
  title={Comparing the ability of a series of viral protein-expressing plasmid DNAs to protect against H5N1 influenza virus},
  author={Quanjiao Chen and Haimen Kuang and Huadong Wang and Fang Fang and Zhongdong Yang and Zhiping Zhang and Xianen Zhang and Ze Chen},
  journal={Virus Genes},
  year={2008},
  volume={38},
  pages={30-38}
}
Avian influenza has been regarded as a human health threat. A major measure to prevent its outbreak is vaccination. In this study, a series of expression plasmids carrying the hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), matrix protein 1 (M1), and matrix protein 2 (M2) genes, respectively, of the avian influenza virus (AIV) A/Chicken/Henan/12/2004(H5N1) strain were constructed. These plasmids were administered to mice by electroporation (50 μg for each per administration, 1–5… CONTINUE READING