Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis

  title={Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis},
  author={John F Wambaugh and Hugh A. Barton and R. Woodrow Setzer},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
Selecting the appropriate pharmacokinetic (PK) model given the available data is investigated for perfluorooctanoic acid (PFOA), which has been widely analyzed with an empirical, one-compartment model. This research examined the results of experiments [Kemper R. A., DuPont Haskell Laboratories, USEPA Administrative Record AR-226.1499 (2003)] that administered single oral or iv doses of PFOA to adult male and female rats. PFOA concentration was observed over time; in plasma for some animals and… CONTINUE READING


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