Comparing independent microarray studies: the case of human embryonic stem cells

@article{SurezFarias2005ComparingIM,
  title={Comparing independent microarray studies: the case of human embryonic stem cells},
  author={Mayte Su{\'a}rez-Fari{\~n}as and Scott A. Noggle and Michael Heke and Ali Hemmati-Brivanlou and Marcelo Magnasco},
  journal={BMC Genomics},
  year={2005},
  volume={6},
  pages={99 - 99}
}
Microarray studies of the same phenomenon in different labs often appear at variance because the published lists of regulated transcripts have disproportionately small intersections. We demonstrate that comparing studies by intersecting lists in this manner is methodologically flawed by reanalyzing three studies of the molecular signature of "stemness" in human embryonic stem cells. There are only 7 genes common to all three published lists, suggesting disagreement. Carefully reanalyzing all… CONTINUE READING

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