Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice.

@article{JorgeNebert2015ComparingGE,
  title={Comparing gene expression during cadmium uptake and distribution: untreated versus oral Cd-treated wild-type and ZIP14 knockout mice.},
  author={Lucia F. Jorge-Nebert and Marina G{\'a}lvez-Peralta and Julio Alberto Landero Figueroa and Maheshika Somarathna and Shintaro Hojyo and Toshiyuki Fukada and Daniel W. Nebert},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={143 1},
  pages={26-35}
}
The nonessential metal cadmium (Cd) is toxic only after entering the cell. Proteins possibly relevant to intracellular Cd accumulation include the divalent metal transporter-1 (DMT1) and all 14 zinc-like iron-like protein (ZIP) importers, 10 zinc transporter (ZnT) exporters, and metallothionein chaperones MT1 and MT2. Comparing oral Cd-treated ZIP14 knockout (KO) with wild-type (WT) mice, we predicted Cd uptake and distribution would be diminished in the KO-because ZIP14 is very highly… CONTINUE READING