Comparing fatal cases involving U-47700
@article{Ruan2016ComparingFC, title={Comparing fatal cases involving U-47700}, author={Xiulu Ruan and Srinivas Chiravuri and Alan David Kaye}, journal={Forensic Science, Medicine, and Pathology}, year={2016}, volume={12}, pages={369-371} }
U-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]N-methylbenzamide) is a novel compound with opioid properties, developed by Upjohn in the 1970s and derived from the earlier opioid analgesic AH-7921 (3,4-dichloro-N{[1-(dimethylamino)-cyclohexyl]methyl}benzamide) [1]. U-47700 is a structural isomer of AH-7921 [2]. AH-7921, which possesses the same potency as morphine, was first identified in 2012 in a seizure purchased over the internet and recently entered the recreational and illicit drug…
27 Citations
DARK Classics in Chemical Neuroscience: U-47700.
- BiologyACS chemical neuroscience
- 2020
This review will capture the >40-year history of U-47700, and go in-depth regarding the synthesis, medicinal chemistry, in vitro/in vivo pharmacology, drug metabolism (from post-mortem over-dose cases), and the societal impact of this DARK Classic in chemical neuroscience.
Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700
- MedicineInternational Journal of Legal Medicine
- 2017
The data concerning U-47700 concentration distribution in postmortem specimens collected after two lethal intoxications showed femoral blood concentrations were lower than the urine/heart blood concentrations and can be defined as high when compared with toxic morphine levels, well known that the interpretation of postmortem drug concentration is a big challenge.
U-47700. An old opioid becomes a recent danger
- ChemistryForensic Toxicology
- 2016
The aim of this review is to summarize the current knowledge about U-47700, regarding its chemistry, synthesis, pharmacology, toxicology and metabolism, as well as its international legal status.
Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: The First Reported Case in the Czech Republic
- ChemistryJournal of forensic sciences
- 2019
A case of near‐fatal U‐47700 intoxication of a man found unconscious (with drug powder residues) is reported, after 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged.
The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning
- ChemistryForensic Toxicology
- 2018
Pre-emptive research on the most likely compounds to emerge next is recommended, so providing drug metabolism and pharmacokinetic data to ensure that new substances are detected early in toxicological samples is recommended.
Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS/MS and Case Series of Fatalities Involving U-48800.
- ChemistryJournal of analytical toxicology
- 2020
Eight medicolegal death investigation cases which had screened positive for U-48800 by liquid chromatography time-of-flight mass spectrometry (LCTOF) were successfully confirmed and quantified using this method.
New synthetic opioid cyclopropylfentanyl together with other novel synthetic opioids in respiratory insufficient comatose patients detected by toxicological analysis
- Medicine, ChemistryClinical toxicology
- 2019
In cases of intoxication without a medical history, the detailed toxicological analysis may reveal new psychoactive substances which are not detected by standard toxicological screening approaches.
Case report: relevance of metabolite identification to detect new synthetic opioid intoxications illustrated by U-47700
- BiologyInternational Journal of Legal Medicine
- 2018
Adding N-desmethyl-U-47700 (and N,N-didesmethyl- U- 47700) in mass spectrum databases used for toxicological screening in order to reduce the risk of false-negative results in intoxication cases involving U-47 700 is suggested.
Blood concentrations of new synthetic opioids
- Medicine, BiologyInternational Journal of Legal Medicine
- 2021
Blood levels of new opioids are extremely difficult to interpret as their high potency creates a risk of respiratory depression even at low doses, which makes it impossible to define concentration ranges, especially the minimum fatal concentrations.
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