Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations

@inproceedings{Reisberg2017ComparingDO,
  title={Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations},
  author={Sulev Reisberg and Tatjana Iljasenko and Kristi L{\"a}ll and Krista Fischer and Jaak Vilo},
  booktitle={PloS one},
  year={2017}
}
Polygenic risk scores are gaining more and more attention for estimating genetic risks for liabilities, especially for noncommunicable diseases. They are now calculated using thousands of DNA markers. In this paper, we compare the score distributions of two previously published very large risk score models within different populations. We show that the risk score model together with its risk stratification thresholds, built upon the data of one population, cannot be applied to another… CONTINUE READING
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