Comparing behavioral responses across multiple assays of stress and anxiety in zebrafish (Danio rerio)

  title={Comparing behavioral responses across multiple assays of stress and anxiety in zebrafish (Danio rerio)},
  author={Ryan Y. Wong and Florence Perrin and Sarah E. Oxendine and Zachary D. Kezios and Susanna Sawyer and Linran Zhou and Simone Dereje and John R Godwin},
Animals encounter stressful situations multiple times throughout their lives and often successfully cope with them. Individuals vary in the nature and intensity of their behavioral and physiological response to stressors, often representing correlated and qualitatively distinct coping styles (e.g., proactive and reactive). These alternative coping styles are ways an animal can overcome a variety of stressful situations, which ultimately can have important fitness consequences. Here we use… 

Repeatability and reliability of exploratory behavior in proactive and reactive zebrafish, Danio rerio

It will be important to continue to investigate how different selective pressures may influence expression of stress coping styles and their effects on the consistency of an animal’s behavior.

Neurochemical and Behavioral Responses to Unpredictable Chronic Mild Stress Following Developmental Isolation: The Zebrafish as a Model for Major Depression.

The results suggest that UCMS increased anxiety-like behavioral responses, whereas developmental isolation altered motor responses during stimulus presentation, which reinforces the utility of combining developmental isolation with UCMS in zebrafish to model depressive-like behavior in humans.

Differences in stress reactivity between zebrafish with alternative stress coping styles

Animals experience stress in a variety of contexts and the behavioural and neuroendocrine responses to stress can vary among conspecifics. The responses across stressors often covary within an

Differential effects of ethanol on behavior and GABAA receptor expression in adult zebrafish (Danio rerio) with alternative stress coping styles

It is found that ethanol-treated proactive individuals showed lower stress-related behaviors than their reactive counterparts and that expression of select GABAA receptor subunits may be one of the underlying mechanisms.

Differential effects of ethanol on behavior and GABAA receptor subunit expression in zebrafish (Danio rerio) with alternative stress coping styles

Differences in stress-related behaviors between stress coping styles may be facilitated in part by expression of select GABAA receptor subunits.

Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment

It is demonstrated that fluoxetine reduces anxiety-related behaviors in wild-derived zebrafish and alters their neurogenomic state and two biological processes, lipid and amino acid metabolic synthesis that characterize differences in the fluoxettine treated fish are identified.

Characterizing the neurotranscriptomic states in alternative stress coping styles

The results show that proactive and reactive stress coping individuals display distinct basal neurotranscriptomic states, which expands the molecular mechanisms of stress coping from one focused on the neurotransmitter systems to a more complex system that involves an organism’s capability to handle neurometabolic loads and allows for comparisons with other animal taxa to uncover potential conserved mechanisms.

Contextual fear learning and memory differ between stress coping styles in zebrafish

This work investigates learning and memory differences in zebrafish displaying proactive and reactive stress coping styles and gains insight into mechanisms that can constrain adaptive behavioral responses.

Analysis of behavioral variables across domains and skin phenotypes in zebrafish: Role of brain monoamines

Specific behavioral endpoints co-varied in terms of the behavioral and neurochemical differences between strains, identifying cross-test domains which included response to novelty, exploration-avoidance, general arousal, and activity.



Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish

Measuring behavioral and endocrine responses to novelty stress in adult zebrafish

This protocol is an easy, inexpensive and effective alternative to other methods of measuring stress responses in zebrafish, thus enabling the rapid acquisition and analysis of large amounts of data.

Behavioral syndromes and the evolution of correlated behavior in zebrafish

Evidence of an activity syndrome is found in zebrafish, as if underlying metabolic costs influence variation in multiple forms of behavior, and a relationship between boldness and aggression was also apparent but depended both on strain and which specific behavior patterns were identified as measures of "boldness.

Strain-specific alteration of zebrafish feeding behavior in response to aversive stimuli.

Significant genetic variation in foraging behavior and the perception of risk in zebrafish is indicated, with a pattern of strain variation consistent with behavioral adaptation to captivity.

Frequency distribution of coping strategies in four populations of brown trout (Salmo trutta)