Comparing antibody and small-molecule therapies for cancer

@article{Imai2006ComparingAA,
  title={Comparing antibody and small-molecule therapies for cancer},
  author={Kohzoh Imai and Akinori Takaoka},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={714-727}
}
The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new… CONTINUE READING
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