Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins.

@article{Beisel2007ComparingAA,
  title={Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins.},
  author={Christian Beisel and Andreas Buness and Ian M Roustan-Espinosa and Britta Koch and Sabine Schmitt and Stefan A. Haas and Marc Hild and Tomonori Katsuyama and Renato Paro},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 42},
  pages={16615-20}
}
Drosophila Polycomb group (PcG) and Trithorax group (TrxG) proteins are responsible for the maintenance of stable transcription patterns of many developmental regulators, such as the homeotic genes. We have used ChIP-on-chip to compare the distribution of several PcG/TrxG proteins, as well as histone modifications in active and repressed genes across the two homeotic complexes ANT-C and BX-C. Our data indicate the colocalization of the Polycomb repressive complex 1 (PRC1) with Trx and the DNA… CONTINUE READING

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