Comparing Mycophenolate Mofetil Regimens for de Novo Renal Transplant Recipients: The Fixed-Dose Concentration-Controlled Trial

@article{Gelder2008ComparingMM,
  title={Comparing Mycophenolate Mofetil Regimens for de Novo Renal Transplant Recipients: The Fixed-Dose Concentration-Controlled Trial},
  author={T. van Gelder and H. Silva and J. D. de Fijter and K. Budde and D. Kuypers and G. Tyd{\'e}n and A. L{\~o}hmus and C. Sommerer and A. Hartmann and Y. Le Meur and M. Oellerich and D. Holt and B. T{\"o}nshoff and P. Keown and S. Campbell and R. Mamelok},
  journal={Transplantation},
  year={2008},
  volume={86},
  pages={1043-1051}
}
Background. Fixed-dose mycophenolate mofetil (MMF) reduces the incidence of acute rejection after solid organ transplantation. The Fixed-Dose Concentration Controlled trial assessed the feasibility and potential benefit of therapeutic drug monitoring in patients receiving MMF after de novo renal transplant. Methods. Patients were randomized to a concentration-controlled (n=452; target exposure 45 mg hr/L) or a fixed-dose (n=449) MMF-containing regimen. The primary endpoint was treatment failure… Expand
The CLEAR study: a 5-day, 3-g loading dose of mycophenolate mofetil versus standard 2-g dosing in renal transplantation.
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