Comparing Bacterial Communities Inferred from 16s Rrna Gene Sequencing and Shotgun Metagenomics

@article{Shah2011ComparingBC,
  title={Comparing Bacterial Communities Inferred from 16s Rrna Gene Sequencing and Shotgun Metagenomics},
  author={Neethu Shah and Haixu Tang and Thomas G. Doak and Yuzhen Ye},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2011},
  pages={
          165-76
        }
}
  • Neethu Shah, Haixu Tang, +1 author Yuzhen Ye
  • Published 2011
  • Biology, Medicine, Computer Science
  • Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
16S rRNA gene sequencing has been widely used for probing the species structure of a variety of environmental bacterial communities. Alternatively, 16S rRNA gene fragments can be retrieved from shotgun metagenomic sequences (metagenomes) and used for species profiling. Both approaches have their limitations-16S rRNA sequencing may be biased because of unequal amplification of species' 16S rRNA genes, whereas shotgun metagenomic sequencing may not be deep enough to detect the 16S rRNA genes of… Expand
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