Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation.

@article{Oliveira2002ComparedTM,
  title={Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation.},
  author={Jos{\'e} Luiz G{\'o}es de Oliveira and Paula Dias Pinto Xavier and Susana Moreira Sampaio and Castro Henriques and Isabel Salom{\'e} Tavares and Armando Augusto Mendes and Manuel Pestana},
  journal={Transplantation},
  year={2002},
  volume={73 6},
  pages={
          915-20
        }
}
BACKGROUND The new immunosuppressive drug Rapamycin (Rapa) is endowed with a mechanism of action that is distinct from that of calcineurin inhibitors. It has been claimed that Rapa does not significantly modulate either the cytokine expression or the transcription of several growth factors in mitogen-activated T cells. Previously, we reported that fine-needle aspiration biopsy (FNAB) sample cultures synthesize a large array of cytokines, and some of them may be powerful predictors of acute… CONTINUE READING

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