Compared properties of central and peripheral binding sites for phencyclidine.

Abstract

Phencyclidine and its derivatives bind specifically and reversibly to rat brain and peripheral organs. Binding characteristics are different in brain, lung, kidney, heart and liver. Affinities of phencyclidines for the brain receptor but not those for peripheral organs are correlated with the pharmacological activities of phencyclidines as measured in the rotarod test.

Cite this paper

@article{Vincent1980ComparedPO, title={Compared properties of central and peripheral binding sites for phencyclidine.}, author={J. P. Vincent and Jacques Vignon and B Kartalovski and Michel Lazdunski}, journal={European journal of pharmacology}, year={1980}, volume={68 1}, pages={79-82} }