Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types.

@article{Sanders2001ComparativeXM,
  title={Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types.},
  author={John M Sanders and Leo T. Burka and Brian Chanas and Hilary Matthews},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={61 1},
  pages={54-61}
}
The use of transgenic animals, such as v-Ha-ras activated (TG:AC) and p53+/- mice, offers great promise for a rapid and more sensitive assay for chemical carcinogenicity. Some carcinogens are metabolically activated; therefore, it is critical that the altered genome of either of these model systems does not compromise their capability and capacity for… CONTINUE READING