Comparative whole-transcriptome analysis in Podophyllum species identifies key transcription factors contributing to biosynthesis of podophyllotoxin in P. hexandrum

@article{Kumar2015ComparativeWA,
  title={Comparative whole-transcriptome analysis in Podophyllum species identifies key transcription factors contributing to biosynthesis of podophyllotoxin in P. hexandrum},
  author={Pawan Kumar and Varun Jaiswal and Tarun Pal and Jagdish Singh and Rajinder S. Chauhan},
  journal={Protoplasma},
  year={2015},
  volume={254},
  pages={217-228}
}
Podophyllum species (Podophyllum hexandrum Royle and Podophyllum peltatum) are a major source of deriving anticancer drugs from their major chemical constituent, podophyllotoxin. However, information lacks on regulatory components of podophyllotoxin biosynthesis; therefore, different classes of transcription factors were identified through mining transcriptomes of Podophyllum species and validated through qRT-PCR analysis vis-à-vis podophyllotoxin contents in different tissues/organs of… CONTINUE READING

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