Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein.

@article{Li1997ComparativeVE,
  title={Comparative vasoconstrictor effects of angiotensin II, III, and IV in human isolated saphenous vein.},
  author={Qiuzhu Li and M. Feenstra and Martin Pfaffendorf and L{\'e}on Eijsman and Pieter A. van Zwieten},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={29 4},
  pages={451-6}
}
Elevated levels of angiotensin (Ang II) and its degradation products angiotensin III (Ang III) and angiotensin IV (Ang IV) may contribute to the regulation of vascular tone under various clinical circumstances. We investigated the contractile effects of Ang III and Ang IV in endothelium-denuded human saphenous vein (SV) preparations and compared them with those of Ang II. The veins were suspended in organ chambers, and changes in isometric force were recorded. Ang II (0.1-100 nM), Ang III (1 nM… CONTINUE READING