Comparative ultrastructural characterization of African horse sickness virus-infected mammalian and insect cells reveals a novel potential virus release mechanism from insect cells.

@article{Venter2014ComparativeUC,
  title={Comparative ultrastructural characterization of African horse sickness virus-infected mammalian and insect cells reveals a novel potential virus release mechanism from insect cells.},
  author={Eudri Venter and Christiaan Frederick van der Merwe and Antoinette V. Buys and Henk Huismans and Vida van Staden},
  journal={The Journal of general virology},
  year={2014},
  volume={95 Pt 3},
  pages={642-51}
}
African horse sickness virus (AHSV) is an arbovirus capable of successfully replicating in both its mammalian host and insect vector. Where mammalian cells show a severe cytopathic effect (CPE) following AHSV infection, insect cells display no CPE. These differences in cell death could be linked to the method of viral release, i.e. lytic or non-lytic, that predominates in a specific cell type. Active release of AHSV, or any related orbivirus, has, however, not yet been documented from insect… CONTINUE READING
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