Comparative two-dimensional mapping of prion protein isoforms in human cerebrospinal fluid and central nervous system.

@article{Castagna2002ComparativeTM,
  title={Comparative two-dimensional mapping of prion protein isoforms in human cerebrospinal fluid and central nervous system.},
  author={Annalisa Castagna and Natascia Campostrini and Alessia Farinazzo and Gianluigi Zanusso and Salvatore Monaco and Pier Giorgio Righetti},
  journal={Electrophoresis},
  year={2002},
  volume={23 2},
  pages={339-46}
}
The cellular prion protein (PrP(C)) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein abundant in neurons. Although its precise function is unknown, PrP(C) represents the substrate for the generation of a conformational pathogenic isoform (PrP(Sc)) in human and animal transmissible spongiform encephalopathies, or prion diseases. By applying novel solubilization cocktails, we analyzed normal human brain and cerebrospinal fluid (CSF) PrP(C) by immunoblot of two-dimensional (2-D) gel… CONTINUE READING
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