Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex.

@article{Golby2007ComparativeTR,
  title={Comparative transcriptomics reveals key gene expression differences between the human and bovine pathogens of the Mycobacterium tuberculosis complex.},
  author={Paul Golby and Kim A. Hatch and Joanna Bacon and Rory P Cooney and Paul Riley and Jon A. Allnutt and Jason Hinds and Javier Nu{\~n}ez and Philip David Marsh and R. Glyn Hewinson and Stephen V. Gordon},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 10},
  pages={3323-36}
}
Members of the Mycobacterium tuberculosis complex show distinct host preferences, yet the molecular basis for this tropism is unknown. Comparison of the M. tuberculosis and Mycobacterium bovis genome sequences revealed no unique genes in the bovine pathogen per se, indicating that differences in gene expression may play a significant role in host predilection. To define the key gene expression differences between M. tuberculosis and M. bovis we have performed transcriptome analyses of cultures… CONTINUE READING
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