Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.

@article{Rotger2011ComparativeTO,
  title={Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.},
  author={Margalida Rotger and Judith Dalmau and Andri Rauch and Paul J. McLaren and Steven E Bosinger and Raquel Mart{\'i}nez and Netanya G. Sandler and Annelys Roque and Julia C. Liebner and Manuel Battegay and Enos Bernasconi and Patrick Descombes and Itziar Erkizia and Jacques Fellay and Bernard Hirschel and Jos{\'e} Ma Mir{\'o} and Eduard Palou and Matthias Hoffmann and Marta Massanella and Julia C. Blanco and Matthew B. Woods and Huldrych F. G{\"u}nthard and Paul I W de Bakker and Daniel C. Douek and Guido Silvestri and Javier Martinez-Picado and Amalio Telenti},
  journal={The Journal of clinical investigation},
  year={2011},
  volume={121 6},
  pages={
          2391-400
        }
}
High levels of HIV-1 replication during the chronic phase of infection usually correlate with rapid progression to severe immunodeficiency. However, a minority of highly viremic individuals remains asymptomatic and maintains high CD4⁺ T cell counts. This tolerant profile is poorly understood and reminiscent of the widely studied nonprogressive disease model of SIV infection in natural hosts. Here, we identify transcriptome differences between rapid progressors (RPs) and viremic nonprogressors… CONTINUE READING
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