Comparative transcriptome analysis of Brucella melitensis in an acidic environment: Identification of the two-component response regulator involved in the acid resistance and virulence of Brucella.

@article{Liu2016ComparativeTA,
  title={Comparative transcriptome analysis of Brucella melitensis in an acidic environment: Identification of the two-component response regulator involved in the acid resistance and virulence of Brucella.},
  author={Qianhong Liu and Xingyu Liu and Feng Yan and Yuhua He and Jie Wei and Yuanyuan Zhang and Lu Liu and Youpeng Sun},
  journal={Microbial pathogenesis},
  year={2016},
  volume={91},
  pages={92-8}
}
Brucella melitensis, encounters a very stressful environment in phagosomes, especially low pH levels. So identifying the genes that contribute to the replication and survival within an acidic environment is critical in understanding the pathogenesis of the Brucella bacteria. In our research, comparative transcriptome with RNA-seq were used to analyze the changes of genes in normal-medium culture and in pH4.4-medium culture. The results reveal that 113 genes expressed with significant… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Whole genome sequence comparison of ten diagnostic brucellaphages propagated on two Brucella abortus hosts

  • J. Farlow E. Tevdoradze, A. Kotorashvili, N. Skhirtladze, I. Antadze, S. Gunia
  • Virol . J .
  • 2015

V

  • T. M. Silva, J. P. Mol, M. G. Winter
  • Atluri, M.N. Xavier, S.F. Pires, et al., The…
  • 2014
1 Excerpt

Inactivation of the ABC transporter ATPase gene in Brucella abortus strain 2308 attenuated the virulence of the bacteria

  • V. Jubier-Maurin Al Dahouk, H. Neubauer, S. Kohler
  • Veterinary Microbiol .
  • 2013

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