Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats.

  title={Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats.},
  author={Irvin R. Schultz and J L Merdink and Alberto Gonz{\'a}lez-Le{\'o}n and Richard J. Bull},
  journal={Toxicology and applied pharmacology},
  volume={158 2},
Chloro, bromo, and mixed bromochloro haloacetates (HAs) are by-products of drinking water disinfection and are hepatocarcinogenic in rodents. We compared the toxicokinetics of a series of di-HAs, dichloro (DCA), bromochloro (BCA), dibromo (DBA) and tri-HAs: trichloro (TCA), bromodichloro (BDCA), chlorodibromo (CDBA), and tribromo (TBA) after iv and oral dosing (500 micrometer/kg) in male F344 rats. The blood concentrations of the HAs after iv injection declined in a bi-exponential manner with a… CONTINUE READING


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