Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

@article{Stblo2000ComparativeTO,
  title={Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells},
  author={Miroslav St{\'y}blo and Luz M. Del Razo and Libia Vega and Dori R. Germolec and Edward L. Lecluyse and Geraldine A. Hamilton and William Reed and Changqing Wang and William Cullen and David J. Thomas},
  journal={Archives of Toxicology},
  year={2000},
  volume={74},
  pages={289-299}
}
Abstract. Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). According to the postulated metabolic scheme, the methylation of iAs yields methylated metabolites in which arsenic is present in both pentavalent and trivalent forms. Pentavalent mono- and dimethylated arsenicals are less acutely toxic than iAs. However, little is known about the toxicity of trivalent methylated species. In the work reported here the toxicities of iAs and trivalent and… 
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