Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice.

@article{Bucher1987ComparativeTA,
  title={Comparative toxicity and carcinogenicity of two chlorinated paraffins in F344/N rats and B6C3F1 mice.},
  author={John R. Bucher and Roger H. Alison and Charles A. Montgomery and James Huff and Joseph K. Haseman and D R Farnell and R K Thompson and Jesse Prejean},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1987},
  volume={9 3},
  pages={454-68}
}
The toxicity and carcinogenicity of chlorinated paraffins containing C12 with 60% Cl, and C23 with 43% Cl, were assessed in prechronic and 2-year gavage studies using F344/N rats and B6C3F1 mice of both sexes. Single administrations of chlorinated paraffins were nonlethal in rats and mice, but repeated-dose and 2-year studies demonstrated toxic responses that differed with the paraffins. The C23,Cl43% paraffin produced a granulomatous inflammation in the liver of female rats in 13-week studies… CONTINUE READING