Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice

@article{Fong2007ComparativeTA,
  title={Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice},
  author={Cora J Fong and L. D. Burgoon and K J Williams and Agnes L Forgacs and Timothy R. Zacharewski},
  journal={BMC Genomics},
  year={2007},
  volume={8},
  pages={151 - 151}
}
Uterine temporal and dose-dependent histopathologic, morphometric and gene expression responses to the selective estrogen receptor modulator tamoxifen (TAM) were comprehensively examined to further elucidate its estrogen receptor-mediated effects. These results were systematically compared to the effects elicited by the potent estrogen receptor ligand 17α-ethynylestradiol (EE) to identify pathways similarly and uniquely modified by each compound. Three daily doses of 100 μg/kg TAM elicited a… CONTINUE READING
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