Comparative suppressive effects of tyrosine kinase inhibitors imatinib and nilotinib in models of autoimmune arthritis.

@article{Akashi2011ComparativeSE,
  title={Comparative suppressive effects of tyrosine kinase inhibitors imatinib and nilotinib in models of autoimmune arthritis.},
  author={Naotsugu Akashi and Isao Matsumoto and Yoko Tanaka and Asuka Inoue and Kayo Yamamoto and Naoto Umeda and Yuki Tanaka and Taichi Hayashi and Daisuke Goto and Satoshi Ito and Kaneo Sekiguchi and Takayuki Sumida},
  journal={Modern rheumatology},
  year={2011},
  volume={21 3},
  pages={267-75}
}
Imatinib and nilotinib are inhibitors that selectively target a set of protein tyrosine kinases, including abelson kinase (Abl), together with the chimeric oncoprotein, breakpoint cluster region-abelson kinase (Bcr-Abl), as well as stem cell factor receptor (KIT), platelet-derived growth factor receptor (PDGFR), discoidin domain receptor (DDR), and colony stimulating factor-1 receptor (CSF-1R). The aim of the present study was to investigate whether imatinib or nilotinib was effective against… CONTINUE READING
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