Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazole.

@article{Lanusse1993ComparativeSO,
  title={Comparative sulphoxidation of albendazole by sheep and cattle liver microsomes and the inhibitory effect of methimazole.},
  author={Carlos E. Lanusse and B Nare and Roger K. Prichard},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1993},
  volume={23 3},
  pages={285-95}
}
1. The comparative rates of oxidation of the benzimidazole anthelmintic, albendazole (ABZ), by sheep and cattle liver microsomes, and inhibition by the antithyroid compound methimazole (MTZ) were investigated. 2. ABZ was oxidized to its sulphoxide metabolite (ABZSO) in an NADPH concentration-dependent reaction. Heat inactivation of the microsomal flavin-containing mono-oxygenase system significantly decreased the NADPH consumption of microsomes in the presence of ABZ, MTZ and thiourea. 3… CONTINUE READING

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The comparative rates of oxidation of the benzimidazole anthelmintic , albendazole ( ABZ ) , by sheep and cattle liver microsomes , and inhibition by the antithyroid compound methimazole ( MTZ ) were investigated .
The comparative rates of oxidation of the benzimidazole anthelmintic , albendazole ( ABZ ) , by sheep and cattle liver microsomes , and inhibition by the antithyroid compound methimazole ( MTZ ) were investigated .
The comparative rates of oxidation of the benzimidazole anthelmintic , albendazole ( ABZ ) , by sheep and cattle liver microsomes , and inhibition by the antithyroid compound methimazole ( MTZ ) were investigated .
The comparative rates of oxidation of the benzimidazole anthelmintic , albendazole ( ABZ ) , by sheep and cattle liver microsomes , and inhibition by the antithyroid compound methimazole ( MTZ ) were investigated .
AnthelminticsTherapeutic class ofAlbendazole
The comparative rates of oxidation of the benzimidazole anthelmintic , albendazole ( ABZ ) , by sheep and cattle liver microsomes , and inhibition by the antithyroid compound methimazole ( MTZ ) were investigated .
3 . Oxidation of ABZ , MTZ and thiourea by sheep liver microsomes consumed significantly more NADPH than oxidation by cattle microsomes .
3 . Oxidation of ABZ , MTZ and thiourea by sheep liver microsomes consumed significantly more NADPH than oxidation by cattle microsomes .
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