Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag.

@article{Suhner1998ComparativeST,
  title={Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag.},
  author={Andrea Suhner and Patricia Schlagenhauf and Robert J Johnson and Alois Tschopp and Robert Steffen},
  journal={Chronobiology international},
  year={1998},
  volume={15 6},
  pages={655-66}
}
To compare the impact of various dosage forms of melatonin and placebo on jet lag symptoms, 320 volunteers who had flights over 6 to 8 time zones were recruited for a double-blind, randomized, placebo-controlled study. The volunteers received either melatonin 0.5-mg fast-release (FR) formulation, melatonin 5-mg FR formulation, melatonin 2-mg controlled-release (CR) formulation, or placebo. The study medication was taken once daily at bedtime during 4 days after an eastward flight. The… CONTINUE READING
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