Comparative study on the metabolism of optical gossypol in rats.

  title={Comparative study on the metabolism of optical gossypol in rats.},
  author={Qian Chen and Haixing Chen and H P Lei},
  journal={Journal of ethnopharmacology},
  volume={20 1},
The comparative metabolism of (+)- and (-)-gossypol in rats was studied. After oral administration of the drugs to rats, the half-lives of (+)- and (-)-gossypol in the gastrointestinal tract were found to be 18.4 h and 13.5 h, respectively. The tissue distribution of (+)-gossypol was very similar to that of (-)-gossypol. After oral administration, high drug levels were found in the liver while moderate concentrations were present in the spleen, lungs, blood, heart and kidneys. The drug levels… CONTINUE READING


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