Comparative study on the metabolism of optical gossypol in rats.

@article{Chen1987ComparativeSO,
  title={Comparative study on the metabolism of optical gossypol in rats.},
  author={Qian Chen and Haixing Chen and H P Lei},
  journal={Journal of ethnopharmacology},
  year={1987},
  volume={20 1},
  pages={31-7}
}
The comparative metabolism of (+)- and (-)-gossypol in rats was studied. After oral administration of the drugs to rats, the half-lives of (+)- and (-)-gossypol in the gastrointestinal tract were found to be 18.4 h and 13.5 h, respectively. The tissue distribution of (+)-gossypol was very similar to that of (-)-gossypol. After oral administration, high drug levels were found in the liver while moderate concentrations were present in the spleen, lungs, blood, heart and kidneys. The drug levels… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…