Comparative study on the effects of kynurenic acid and glucosamine-kynurenic acid.

@article{Fvesi2004ComparativeSO,
  title={Comparative study on the effects of kynurenic acid and glucosamine-kynurenic acid.},
  author={Judit F{\"u}vesi and Csaba Somlai and Hajnalka E Nemeth and Hedvig Varga and Zsolt Kis and Tam{\'a}s Farkas and Norbert K{\'a}roly and Marton Benedek Dobszay and Zsuzsa Penke and Botond Penke and L{\'a}szl{\'o} V{\'e}csei and J{\'o}zsef Toldi},
  journal={Pharmacology, biochemistry, and behavior},
  year={2004},
  volume={77 1},
  pages={95-102}
}
Kynurenic acid (KYNA) is the only known endogenous N-methyl-D-aspartate (NMDA) receptor inhibitor and might therefore come into consideration as a therapeutic agent in certain neurobiological disorders. However, its use as a neuroprotective compound is practically excluded because KYNA does not readily cross the blood-brain barrier (BBB). We recently synthetized a new compound, glucosamine-kynurenic acid (KYNA-NH-GLUC), which is presumed to cross the BBB more easily. In this study, the effects… CONTINUE READING

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