Comparative study on the conformation of phalloidin, viroisin, and related derivatives in aqueous solution.

@article{Kobayashi1995ComparativeSO,
  title={Comparative study on the conformation of phalloidin, viroisin, and related derivatives in aqueous solution.},
  author={Nobuhiko Kobayashi and Shuichi Endo and Hiromi Kobayashi and Heinz Faulstich and Thomas Wieland and Eisuke Munekata},
  journal={European journal of biochemistry},
  year={1995},
  volume={232 3},
  pages={726-36}
}
We investigated the conformations of toxic phalloidin and viroisin in aqueous solution using 500-MHz 1H-NMR spectroscopy in conjunction with molecular modeling. The conformations of two non-toxic phalloidin derivatives, secophalloidin and dethiophalloidin, were also correspondingly studied for comparison purposes. Results indicate that the non-toxic peptides have a multiple conformation, whereas the toxic peptides are comprised of a rigid molecule. It was found that the conformation of… CONTINUE READING

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