Comparative study on the analytical performance of different detectors for the liquid chromatographic analysis of tobramycin.

@article{Chopra2010ComparativeSO,
  title={Comparative study on the analytical performance of different detectors for the liquid chromatographic analysis of tobramycin.},
  author={Shruti Chopra and Geert Vanderheyden and Jos a Hoogmartens and Ann Van Schepdael and Erwin Adams},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2010},
  volume={53 2},
  pages={151-7}
}
Pulsed electrochemical detection (PED) with a triple step potential-time waveform has been used successfully for the direct detection of several non-chromophoric aminoglycosides at alkaline pH following ion-pair liquid chromatography (LC). This direct detection method has helped to overcome the various flaws observed in the analysis of aminoglycosides using time consuming derivatization procedures. However, this technique also suffers from some disadvantages. Hence, improvements of PED as well… CONTINUE READING