Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes.

  title={Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes.},
  author={Hoe Jin Kang and Preeti Makkar and Andrew Reyes Padalhin and Gun Hee Lee and Soo Bin Im and Byong-Taek Lee},
  journal={Materials science \& engineering. C, Materials for biological applications},
  • H. KangP. Makkar Byong-Taek Lee
  • Published 1 May 2020
  • Materials Science, Biology, Medicine, Engineering
  • Materials science & engineering. C, Materials for biological applications

A 3D-printed Sn-doped calcium phosphate scaffold for bone tissue engineering

The 3D printing of Sn@TCP scaffolds with enhanced mechanical properties and osteoblast-inducing activity show great promise as scaffold materials in bone tissue engineering applications.

Current Application of Beta-Tricalcium Phosphate in Bone Repair and Its Mechanism to Regulate Osteogenesis

A deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration.

Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells

Investigation of the effect of inorganic phosphate at a series of concentration on migration and osteogenic differentiation of human bone marrow -derived mesenchymal stem cells showed 4-10 mM Pi could promote the migration, osteogenic differentiate, and mineralization of hBM-MSCs.

Bone Regeneration by Multichannel Cylindrical Granular Bone Substitute for Regeneration of Bone in Cases of Tumor, Fracture, and Arthroplasty

High-strength multichannel granules could be employed as versatile bone substitutes for the treatment of a wide range of orthopedic conditions.



Bone regeneration strategy by different sized multichanneled biphasic calcium phosphate granules: In vivo evaluation in rabbit model

In vivo investigation in a rabbit model indicated that all four samples formed significantly better bone than the control after four weeks and eight weeks of implantation, and in vitro biocompatibility and cytotoxicity was assessed using MC3T3-E1 osteoblast-like cells using MTT assay and confocal imaging.

On the structural, mechanical, and biodegradation properties of HA/β-TCP robocast scaffolds.

The findings from this work indicate that composite calcium phosphate scaffolds with customer-designed chemistry and architecture may be fabricated by a robotic-assisted deposition method.

A combination of biphasic calcium phosphate scaffold with hyaluronic acid-gelatin hydrogel as a new tool for bone regeneration.

In vivo expression of extracellular matrix proteins demonstrated that this novel bone substitute holds great promise for use in stimulating new bone regeneration and showed that the implanted HyA-Gel-loaded BCP scaffold begins to degrade within 3 months after implantation.

Biphasic calcium phosphate bioceramics: preparation, properties and applications

The potential uses of BCP ceramic as scaffold for tissue engineering, drug delivery system and carrier of growth factors, and as an injectible biomaterial in a polymer carrier are demonstrated.

An in vivo study on bone formation behavior of microporous granular calcium phosphate.

Results are encouraging and show that the microporous granular biomaterials of HA, β-TCP and biphasic compositions show similar results with perfect osseointegration, as well as bone tissue neoformation results obtained from in vivo assays.

Beta-tricalcium phosphate granules improve osteogenesis in vitro and establish innovative osteo-regenerators for bone tissue engineering in vivo

F Fluorochrome labelling, micro-computed tomography and histological staining analyses indicated that the osteo-regenerator with two holes perforating the femur promoted significantly greater bone regeneration compared with the osteospecialist with a periosteum incision.

Phosphonate-chitosan functionalization of a multi-channel hydroxyapatite scaffold for interfacial implant-bone tissue integration.

The modified HAp scaffolds exhibited early interfacial implant-bone tissue integration with enhanced new bone formation and high potential for use in segmental bone defects.