Comparative study of the teratogenicity of phenobarbitone, diphenylhydantoin and carbamazepine in mice.

@article{Fritz1976ComparativeSO,
  title={Comparative study of the teratogenicity of phenobarbitone, diphenylhydantoin and carbamazepine in mice.},
  author={Harald Fritz and Dieter Mueller and Robert Hess},
  journal={Toxicology},
  year={1976},
  volume={6 3},
  pages={323-30}
}
Three selected anticonvulsants, phenobarbitone (PHB), diphenylhydantoin (DPH) and carbamazepine (CAA) were examined for embryotoxic and teratogenic activity in albino mice. After oral treatment of the dams during the period of organogenesis (days 6-15 of gestation) with both PHB and DPH in doses causing marked symptoms and signs of toxicity (40 and 170 mg/kg/day respectively), an abnormally high incidence of cleft palate was observed in the foetuses (4.3% and 9.3% resp.). In a cumulative… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.