Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes

Abstract

The hERG channel is a voltage-gated potassium channel found in cardiomyocytes that contributes to the repolarization of the cell membrane following the cardiac action potential, an important step in the regulation of the cardiac cycle. The lipids surrounding K+ channels have been shown to play a key role in their regulation, with anionic lipids shown to… (More)
DOI: 10.1007/s00249-017-1201-2

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