Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells.

@article{Faria2016ComparativeSO,
  title={Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells.},
  author={Juliana Machado de Faria and J F deS Barbosa and Od{\'i}lia Queir{\'o}s and Roxana Falc{\~a}o Moreira and F{\'e}lix Carvalho and Ricardo Jorge Dinis-Oliveira},
  journal={Toxicology},
  year={2016},
  volume={359-360},
  pages={1-10}
}
Opioid therapy and abuse are increasing, justifying the need to study their toxicity and underlying mechanisms. Given opioid pharmacodynamics at the central nervous system, the analysis of toxic effects in neuronal models gains particular relevance. The aim of this study was to compare the toxicological effects of acute exposure to tramadol and tapentadol in the undifferentiated human SH-SY5Y neuroblastoma cell line. Upon exposure to tramadol and tapentadol concentrations up to 600μM, cell… CONTINUE READING