Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer.

@article{Sari2011ComparativeSO,
  title={Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancer.},
  author={Ebru Sari and Gulnur Guler and Mutlu Hayran and Ibrahim Halil Gullu and Kadri Altundag and Yavuz Ozişik},
  journal={Medical oncology},
  year={2011},
  volume={28 1},
  pages={57-63}
}
Recent studies have shown some degrees of discordance in ER, PR and HER-2 immunohistochemical expression between primary and recurrent/metastatic lesions (RML). Analysis was made on 78 patients with MBC whose ER, PR and/or HER-2 status were known both on the tissue samples of primary and RML. Among the RML sites, 29.5% were locoregional, 70.5% were distant metastatic sites. Among 75 patients with known ER expression on both primary and RML, 36% (n = 27) showed discordance on ER expression… CONTINUE READING

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