Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.

@article{Vokhmyanina2012ComparativeSO,
  title={Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.},
  author={Olga A Vokhmyanina and Eugenia M. Rapoport and Sabine Andr{\'e} and Vyacheslav V Severov and Ivan M Ryzhov and Galina V. Pazynina and Elena Korchagina and Hans-Joachim Gabius and Nicolai V. Bovin},
  journal={Glycobiology},
  year={2012},
  volume={22 9},
  pages={
          1207-17
        }
}
Adhesion/growth-regulatory galectins (gals) exert their functionality by the cis/trans-cross-linking of distinct glycans after initial one-point binding. In order to define the specificity of ensuing association events leading to cross-linking, we recently established a cell-based assay using fluorescent glycoconjugates as flow cytometry probes and tested it on two human gals (gal-1 and -3). Here we present a systematic study of tandem-repeat-type gal-4, -8 and -9 loaded on Raji cells resulting… CONTINUE READING
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